7,354 research outputs found

    An update on myasthenia gravis

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    Myasthenia gravis (MG) is an autoimmune disease characterised by autoantibodies against acetylcholine receptors at neuromuscular junctions, resulting in defective neuromuscular transmission. The characteristic features are fatigability and fluctuating weakness of skeletal muscles. It commonly presents with diplopia or unilateral ptosis, which are worse in the evenings. Respiratory muscle weakness may result in respiratory failure. MG is associated with various autoimmune diseases, and thymic hyperplasia or thymoma. An early diagnosis depends on a high index of suspicion, and is confirmed using tensilon test, and electromyography (EMG), and by a raised acetylcholine receptor antibody titre. Symptomatic treatment consists of cholinesterase inhibitors, corticosteroids and other immunosuppressants. Plasmapheresis or pooled intravenous human IgG (IVIgG) provides rapid but short-term relief for acute exacerbations. Thymectomy provides long-term control for patients with thymic hyperplasia, and is essential for thymomas.published_or_final_versio

    Reversible acute renal failure in a patient with IgA nephropathy

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    Reversible acute renal failure is a rare complication of IgA nephropathy. We report a patient with IgA nephropathy who developed acute renal failure after an episode of gross haematuria. Renal biopsy revealed extensive acute tubular damage and red blood cell casts. His renal failure recovered spontaneously without specific treatment. The clinical and pathological features of this IgA nephropathy complication are discussed.published_or_final_versio

    A Correlation Study Between In-brace Correction, Compliance To Spinal Orthosis And Health-related Quality Of Life Of Patients With Adolescent Idiopathic Scoliosis

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    Background It has been proposed that in-brace correction is the best guideline for prediction of the results of brace treatment for patients with Adolescent Idiopathic Scoliosis (AIS). However, bracing may be a stressful experience for patients and bracing non-compliance could be psychologically related. The purpose of this study was to assess the correlation between brace compliance, in-brace correction and QoL of patients with AIS. Methods Fifty-five patients with a diagnosis of AIS were recruited. All were female and aged 10 years or above when a brace was prescribed, none had undergone prior treatment, and all had a Risser sign of 0–2 and a Cobb angle of 25-40°. The patients were examined in three consecutive visits with 4 to 6 months between each visit. The Chinese translated Trunk Appearance Perception Scale (TAPS), the Chinese translated Brace Questionnaires (BrQ) and the Chinese translated SRS-22 Questionnaires were used in the study. The in-brace Cobb angle, vertebral rotation and trunk listing were also measured. Patients’ compliance, in-brace correction and patients’ QoL were assessed. To identify the relationship among these three areas, logistic regression model and generalized linear model were used. Result For the compliance measure, a significant difference (p = 0.008) was detected on TAPS mean score difference between Visit 1 and Visit 2 in the least compliant group (0–8 hours) and the most compliant group (17–23 hours). In addition, a significant difference (p = 0.000) was detected on BrQ mean score difference between Visit 2 and Visit 3 in the least compliant group (0–8 hours) and the most compliant group (17–23 hours). For the orthosis effectiveness measure, no significant difference was detected between the three groups of bracing hours (0–8 hours, 9–16 hours, 17–23 hours) on in-brace correction (below 40% and 40% or above). For the QoL measure, no significant difference was detected between the two different in-brace correction groups (below 40% and 40% or above) on QoL as reflected by the TAPS, BrQ and SRS-22r mean scores. Conclusion The results showed a positive relationship between patients’ brace wear compliance and patients’ QoL. Poor compliance would cause a lower QoL.published_or_final_versio

    Development of packaging and electrical interfacing for electrical vehicles

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    Author name used in this publication: K. W. E. ChengAuthor name used in this publication: S. L. HoRefereed conference paper2006-2007 > Academic research: refereed > Refereed conference paperVersion of RecordPublishe

    Characteristics of local migraine patients

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    Management of hepatocellular carcinoma with portal vein tumor thrombosis: Review and update at 2016

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    Fibrillary glomerulonephritis: a case report

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    Fibrillary glomerulonephritis is a recently recognised condition. The usual presentation is heavy proteinuria. The diagnosis is established by demonstration of the characteristic Congo-red negative, randomly arranged microfibrils in the glomeruli by electron microscopy. At present, there is no proven effective treatment for this condition and the prognosis is generally poor. The first case of fibrillary glomerulonephritis diagnosed in Hong Kong is reported here in a 38-year-old woman.published_or_final_versio

    Down-regulation of Sox7 is associated with aberrant activation of Wnt/b-catenin signaling in endometrial cancer

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    香港結核病患者的特徵與治療結果

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    OBJECTIVES: To identify the general characteristics of patients with tuberculosis, and to evaluate their treatment outcomes. DESIGN: Retrospective study. SETTING: Tuberculosis and Chest Service, Department of Health, Hong Kong. SUBJECTS AND METHODS: All patients with tuberculosis registered for treatment from 1 January 1996 to 31 December 1996 were included in the study. Information was extracted from their medical records at treatment commencement and at 12 and 24 months after treatment was instigated. Data gathered included demographic data, past treatment, site of disease, case category, treatment regimen, bacteriological status, and treatment outcome. RESULTS: There were 5757 patients for analysis. Approximately one third of patients were aged 60 years or older, and 69.1% were male. Pulmonary disease alone occurred in 77.7% of patients, while both pulmonary and extrapulmonary diseases occurred in 8.6%. New patients comprised 84.6% of cases, and 16.3% had concomitant illnesses. There was excess risk of disease among patients who were male, elderly, or who had silicosis. Only 0.1% of patients were co-infected with human immunodeficiency virus infection. Among the 5757 cases evaluated, 1324 (23.0%) were new patients with a positive sputum smear, 299 (5.2%) were patients who were retreated with a positive sputum smear, and 4134 (71.8%) were new or retreatment patients with a negative sputum smear. The overall treatment completion rates at 12 and 24 months were 80.4% and 84.8%, respectively. Males and patients aged 60 years or older had lower treatment completion rates. Non-adherence, transfer to other services, and mortality among the elderly were key factors influencing treatment outcomes. Co-morbidity was associated with better case-holding, and this more than compensated for its effect on prolongation of treatment and mortality. CONCLUSIONS: There was an excess risk of tuberculosis among male and elderly patients, who also had a less favourable outcome. Active screening of clearly identified risk groups may be appropriate but requires the completion of more in-depth studies and careful cost-effectiveness analyses. Further efforts with respect to case-holding are indicated to address treatment defaulting and transfer rates.published_or_final_versio
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